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Risk of bias assessment Two reviewers independently appraised the quality of the studies using the Cochrane risk of bias version 2 (RoB-2) tool [30] and disagreements were resolved through consensus
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With regard to the above-mentioned concerns, therapy based on L-thyroxine (with or without T3), which has seemed to be only a symptomatic one, turned out to exert a simultaneous immunomodulatory effect
