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Hendrikx T, Duan Y, Wang Y, Oh JH, Alexander LM, Huang W, et al

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Aim for 250 to 500 milligrams of EPA plus DHA each day or consume fatty fish twice a week

1 Introduction Chronic obstructive pulmonary disease (COPD) is a highly prevalent, progressive respiratory disorder characterized by persistent airway inflammation, irreversible airflow limitation, and alveolar destruction ( Emerging evidence now positions ferroptosis not merely as a consequence but as a key amplifier of COPD pathology, particularly through its dynamic interplay with immune dysregulation ( 2 Ferroptosis: a novel form of regulated cell death Ferroptosis is a distinctive type of regulated cell death that significantly differs from apoptosis, necrosis, and autophagy