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Although they have provided key insight into numerous secondary injury mechanisms and therapy development (1719), there are several limitations to the existing literature: (1) lengthy observation periods of the model organism, (2) high cost for experimentation and associated costs, (3) relatively difficult and lengthy genetic manipulations, and (4) ethical concerns regarding a large number of mammals experiencing pain and debilitating injury

- Pigs: 0,5 ml/20 kg l.w., once a day intramuscularly for 3 days

doi: 10.1038/npp.2014.326

[DOI] [PubMed] [Google Scholar] 40.Lash L.H

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