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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Martin-Hidalgo D., Bragado M.J., Batista A.R., Oliveira P.F., Alves M.G

doi: 10.1016/j.amjhyper.2003.12.019

Whillier et al., 2011)

For further prognostic evaluation and clinical decision-making, breast cancer can be classified into three subgroups based on immunohistochemical staining results for ER, PR, and HER2: HR-positive/HER2negative (HR+/HER2, ~70%), HER2positive (HER2+, ~1520%), and triple-negative breast cancer [TNBC, HR-negative (HR-), HER2, ~15%]

The lack of function of the enzymes of glutathione production in these conditions suggests that more efficient resolution of the effects of glutathione depletion may require the administration of the complete molecule as demonstrated in vitro in the HIV + macrophage study [52]