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Surgical alterations to the digestive system can affect the areas responsible for B12 absorption

Our results unequivocally demonstrate that Gcg gene expression is upregulated and glucagon secretion is also significantly increased in cells of GCGR-KO mice

doi:10.1371/journal.pone.0022792

5-amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide using S-adenosylmethionine (SAM)

B12 is water-soluble and excess amounts are typically excreted

Understanding how GHK-CU affects your body individually makes it easier to assess what additional compounds contribute when added later