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10.1111/jnc.13348 53

Classified as a growth hormonederived metabolic signaling peptide, AOD 9604 functions as a selective modulator of adipose tissue pathways, enabling targeted investigation of lipolysis without engagement of canonical growth hormone receptor signaling

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Harvested supernatant were purified using Protein A affinity chromatography and polished using SEC

Alterations in microbial communities and their metabolites have been linked to key pathological features of PCOS (116, 117), including insulin resistance, hyperandrogenism, and chronic low-grade inflammation, supporting the concept of a gutmetabolismreproductive axis in which intestinal microbial ecosystems influence both metabolic and endocrine homeostasis (23, 73)