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pylori is relatively small (~ 1.6 Mbp) and compact (~ 1500 ORF), the high level of diversity can complicate comparative genomics analyses between many strains, and new methods of analysis have to be developed, such as a feature frequency profiling (FFP), an alignment-free analysis approach (Van Vliet and Kusters 2015)

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S., Heit, B

But what exactly does it do