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C.et al (2015)

Daily doses from 200 to 2,400 milligrams are considered safe, but higher doses offer no extra benefits

Both compounds have been studied extensively for decades and are safe when taken in the recommended doses

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The relevant mechanisms are as follows (shown in Figure 2 )

In addition to suppressing the HPA axis, various cancer therapies such as glucocorticoids, radiation, and some chemotherapy medications may also lower energy levels due to the dampened stress response
