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Through stable isotope tracing and chromatin-immunoprecipitation (ChIP) assay, we also found that ACTL6A promotes GSH synthesis by upregulating the rate-limiting enzyme GCLC as a co-transcription factor

This makes red blood cells fragile or scarce

Fang, M

We hypothesize that irisin reduces lactate synthesis by inhibiting the HIF-1/LDHA pathway via SIRT1-mediated deacetylation and repairs mitochondrial function through the PGC-1/UCP2 pathway, ultimately improving neuronal damage

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