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Genes that are involved in lipid accumulation are negatively regulated by Nrf2 [87], and this finding supports the relevance of Nrf2 in NAFLD patients
Increase in AsA-GSH content, reduced AsA-GSH redox status accompanied by AsAGSH cycle enzymes such as GR, MDHAR, APX and DHAR, clearly evident that AsAGSH cycle played a crucial role for scavenging ROS in the tolerant variety of A
The BAX/Bcl2 ratio was 8-fold higher compared to the control group
Others have identified astrocytes as a target for the neuroprotective effects of UA, demonstrating effects on astrocytic glutathione and Nrf2, and providing further support for the involvement of UA in antioxidative processes 52
IGF-1 LR3 works by activating specific signaling pathways that promote growth and cell division, binding to IGF-1 receptors, and influencing various biological processes
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