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The number of single or colocalized cells, the latter identified with overlapping TH + and EBF3 + staining, was performed manually by two independent investigators using the Cell Counter plugin in ImageJ

Integrating natural compounds and nanoparticle-based drug delivery systems: a novel strategy for enhanced efficacy and selectivity in cancer therapy

Abbreviations BPN: Benign pulmonary nodules PLC: Primary lung cancer HPG: Healthy population group CEA: Carcinoembryonic antigen Cyfra21-1: Cytokeratin 19 fragment NSE: Neuron-specific enolase ProGRP: Gastrin-releasing peptide precursor SCAA: Squamous cell carcinoma antigens PCA: Principal component analysis PLS-DA: Partial least squares discriminant analysis OPLS-DA: Orthogonal partial least squares discriminant analysis Par: Pareto variance scaling VIP: Variable importance in the projection FC: Fold change ROC: Receiver operating characteristic curve AUC: Area under the curve References Sung HA-O et al

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Oxford Press

Spicer JD, Shewale J, Correa AM, Heymach JV, Antonoff MB , Hofstetter W, Mehran R, Roth J, Rice D, Sepesi B, Vaporciyan AA, William W, Walsh G, Swisher S