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doi: 10.1016/j.taap.2006.01.003 Vlassara H, and Striker GE ( 2011 )

The researchers did not notice significant action on ERK1/2, JNK1/2, or NO secretion

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Exploratory study of carboplatin plus the copper-lowering agent trientine in patients with advanced malignancies

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Based on basic experimental research Agonists or inhibitors The Nrf2 pathway and its downstream oxidative-antioxidant signaling pathways, as well as, the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) inflammatory signaling pathways, strongly influence the development and progression of PF [73, 74]