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doi: 10.1038/nri2094 [DOI] [PubMed] [Google Scholar] 43.Mills CD, Kincaid K, Alt JM, Heilman MJ, Hill AM

These oligomers are now recognized as critical contributors to early synaptic dysfunction and memory impairment in AD (Haass and Selkoe, 2007

Ambroxol (Amb) Ambroxol, an active metabolite of bromhexine, is approved for the treatment of airway diseases in several countries

One of the major contributors is the stepwise oxidation of glutamine to generate the TCA cycle intermediate -ketoglutarate ( -KG), i.e., glutaminolysis

It reduces wrinkles and fine lines along with other signs of ageing

In some cases, this is through TRIM actions on transcription factors that activate expression of autophagy-related genes
