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Additionally, treatment of DIO mice with the NNMT inhibitor resulted in a substantial ~35% decrease ( P 30% decrease in adipocyte size ( P 40% decrease in adipocyte volume (data not shown) compared to control DIO mice

After binding with the surface receptor on target cells, growth hormone can activate the JAK-STAT signaling pathway and stimulate the production of insulin-like growth factor 1 (IGF-1), which is known to exert a growth-stimulating effect on different tissues

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