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The NDA submission was partly based on topline results from the ongoing single location BHV4157-206-RWE study (NCT06529146), in which troriluzole 200 mg administered orally once daily led to a 5070% slower rate of decline from baseline in the functional Scale for the Assessment and Rating of Ataxia (f-SARA) in all SCA genotypes at 3 years compared to an external control arm. Data from the BHV4157-206 study (NCT03701399) also demonstrated disease stabilization in the SCA3 genotype and a reduction in falls in all SCA genotypes compared to placebo over 48 weeks. If approved, troriluzole will be the first and only medication indicated for the treatment of SCA

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A prefilled syringe is a sterile, single dose syringe that comes preloaded with a specific drug dose, eliminating the need for manual preparation by a compounding pharmacy or healthcare provider

Published mid-stage research has reported weight and metabolic changes in selected study groups, but those findings do not make retatrutide a routine treatment

The power of pairing GLP-1s with Weight Watchers Science shows that weight-loss medications should be combined with lifestyle changes