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ANALYSIS METHODOLOGY For a deeper understanding of where off-label GLP-1 uses are emerging, Storyful Intelligence analyzed 29.9k mentions across conversations on X, Facebook, Reddit, and Instagram, from February 1, 2024, to March 24, 2025

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We identified that GLP-1R agonism reduced ethanol consumption, mitigated ethanol-induced upregulation of several liver metabolizing enzymes, including Cyp2e1 and also reduced Cyp2e1 independent of ethanol intake