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After 26 weeks, the levels of hs-CRP and endothelin-1 decreased (27.5% and 18.75%, respectively) in the exenatide arm whereas the levels of fibrinogen, monocyte chemoattractant protein-1, leptin and endothelin-1 increased in the insulin glargine arm (13.4%, 30.2%, 47.5%, and 80%, respectively) [45]

In 2019, the FDA approved the first oral GLP-1 agonist (oral semaglutide, Rybelsus)

And because obesity is chronic, requiring indefinite treatment to maintain results, the lifetime value of each patient is extraordinary

Behavioral and care management support are important factors

10.1016/j.tem.2012.11.008
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