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Pancreatitis The US Food and Drug Administration (FDA) and the European Medicines Agency highlighted concerns over whether incretin-based therapies may be damaging to the pancreas by conducting extensive studies

FDA-approved GLP-1 medications, including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), follow a titration schedule

Some preproglucagon-expressing neurons in the nucleus tractus solitarius of the brain stem have also been shown to synthesise GLP-1 (2)

doi: 10.1021/jm9909645 [DOI] [PubMed] [Google Scholar] 100

Further, data on GLP-1 usage is limited internationally, and examining the global landscape for these drugs primarily highlights the scarcity of pediatric specific evidence and guidelines across countries