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Patients were randomized 1:1:1:1 to survodutide 2.4, 4.8, or 6 mg weekly, or placebo for 48 weeks

They delay gastric emptying as to decrease the physical feeling of needing to eat and they target the brains dopamine reward pathways which can dull the reward of highly desired foods

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doi: 10.1186/1742-2094-9-276 10 NauckMAQuastDRWefersJMeierJJ

revealed that liraglutide attenuated the phosphorylation of JAK2 and STAT3 in AGE-stimulated endothelial cells and the kidney of db/db mice (Zitman-Gal et al., 2019)

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