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Research suggests that GLP-1 agents exert direct cardioprotective effects through anti-inflammatory mechanisms and improved endothelial function

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Reducing Appetite The influence of GLP-1 on brain regions is rather direct

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In cellular models, GLP-1R activation attenuates the expression of proinflammatory mediators such as TNF-, IL-1, and IL-6, alleviates ER stress, and improves mitochondrial function

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in 2023 in the New England Journal of Medicine the same research group responsible for the STEP semaglutide trials and SURMOUNT Tirzepatide trials

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Cardiovascular and kidney benefits of SGLT-2is and GLP-1RAs according to baseline blood pressure in type 2 diabetes: a systematic meta-analysis of cardiovascular outcome trials

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The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

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