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Description
This article describes GLP-1 peptide characteristics and the mechanisms mediating its known role in increasing insulin, decreasing glucagon, delaying gastric emptying, and promoting satiety

In the intracellular side, a sharp kink located in the conserved Pro 6.47b -X-X-Gly 6.50b motif pivoted the intracellular tip of TM6 to move outwards by 19.3 (measured by C atom of K344 6.35b ), slightly higher than that seen with the GCGGCGRG s (17.7 ) 4

Mol Neurobiol 2021;58:495979

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Without serotonin-pathway support like 5-HTP or saffron, it only addresses part of the problem

At the highest dose (15 mg), nausea was reported in 31% of patients, diarrhoea in 23%, vomiting in 12.1%, constipation in 11.7%, and indigestion in 11.3%
