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Semaglutide-induced improvement in OXPHOS efficiency did not appear to be related to changes in the mitochondrial lipidome

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GLP-1 and leptin were significantly altered with the intervention, pointing to their involvement in decreased calorie consumption and increased satiety

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Domperidone (10 mg up to three times daily) is an alternative prokinetic agent but has MHRA restrictions due to cardiac risks (QT prolongation) and interactions with CYP3A4 inhibitors

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