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Decreased bone density If we lose muscle mass this will negatively affect bone density, Ortiz-Pujols warned When people dont get enough protein while on these drugs, it can make the problem worse

Stop taking the medication immediately and call your physician

The orientation paper for Phase 3 work in this space and the closest analogue to a methods paper for the registrational program

placebo, -15.22% vs

These events tended to cluster around the weeks when the dose was increased, particularly when subjects moved from 2 mg to 4 mg or later from 8 mg to 12 mg once weekly