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Aging reduces NAD+ synthesis pathways while increasing consumption by enzymes like CD38 and PARPs, activated by inflammation and damage.[13][15] CD38, an immune-related enzyme, ramps up with age, breaking down NAD+ precursors

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Study limitations There were a few study limitations

The additive effects observed when combining NNMT inhibition with exercise indicate that the compound influences molecular pathways distinct from those activated by physical training alone