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Fan H, Yan G, Zhao Z, Hu X, Zhang W, Liu H, et al

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Moreover, these variants suppressed phosphorylation of SHP2 and ERK to a significantly greater extent than STAT3, with the D23L/S117N variant in particular reducing both SHP2 and ERK signaling by approximately 90%, despite retaining approximately 50% STAT3 activation relative to treatment with WT leptin alone (Fig

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doi: 10.3906/sag-2011-139