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The heterogeneity of study populations and interventions across different trials makes it challenging to draw definitive conclusions about optimal treatment approaches

Trials like STEP 1 show rapid weight loss in the first 16 weeks, with continued loss through 68 weeks on medication

How motivated and behaviorally ready is the patient

Unlike GLP-1RAs, none of the DPP-4i tested displayed superiority over the placebo in relation to the primary endpoint and the detailed results of these three trials are described in Table 2

This action does not occur immediately

SGLT1 inhibition also increases postprandial release of the gastrointestinal hormones GLP-1 and polypeptide YY, probably by increasing delivery of glucose to the distal small intestine, thereby regulating glucose and appetite control