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Then, the proprotein convertase Furin recognizes and cleaves a specific sequence in Pro-GDF-8 to form Latent GDF-8, a key step in GDF-8 maturation

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Switching to the oral small molecule glucagon-like peptide-1 (GLP-1) orforglipron after taking injectable GLP-1s helped patients maintain mostbut not allof their weight loss, according to a clinical trial led by Weill Cornell Medicine and NewYork-Presbyterian investigators.

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