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Gliotoxin and related epipolythiodioxopiperazines

In particular, some studies report the ratio of free GSH to GSSG [19, 22,23,24,25,26], whereas others quantify and report total GSH (i.e., free GSH + 2xGSSG) [12, 19, 24, 26,27,28,29,30]

The degree centrality measures focus more on local connectivities, while the betweeness centrality measures focus more on global network topology

Ligand efficiency: a useful metric for lead selection

Two currently available inhibitors, namely, 2-DG and 3-bromopyruvate (3-Br PA), have been used in clinical trials

[DOI] [PMC free article] [PubMed] [Google Scholar] 147.Harbeck N., Gnant M