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this suggests a rapid phase of GLP-1 secretion caused by direct stimulation of L-cells in the upper GI tract and a second phase potentially caused by signals from the upper gut reaching the lower small and perhaps even the large intestine [323,324]

The medication increases activity of norepinephrine and dopamine in the brainneurotransmitters linked to appetite suppression, motivation, and metabolism

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Therefore, almost all scientific guidelines now recommend specific treatments for patients with type 2 diabetes based on CVOTs data, namely adding to metformin a SGLT-2 inhibitor or a GLP-1RA with proven CV disease benefit in patients with type 2 diabetes and CV disease, established kidney disease, or HF [7,8,9,10]

Similar content being viewed by others Introduction Retatrutide was developed to treat diabetes type 2 and obesity (Jastreboff et al

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