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Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress

[DOI] [PMC free article] [PubMed] [Google Scholar] 144.Zhang JV et al

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Pirfenidone (PFD) is a representative antifibrotic drug currently approved for treating IPF

Furthermore, it inhibits inflammatory cascades by suppressing the COX enzyme and prostaglandin E-2 (PGE2), also influencing various molecular signaling pathways related to inflammation, apoptosis, and oxidative stress, like PPAR, PI3K, TLR-4, Akt, mTOR, ERK5, AP-1, TGF-, PAK1, Wnt, -catenin, Shh, Rac1, p38MAPK, EBP, NLRP3 inflammasome, Nrf2, Notch-1, AMPK, STAT3, and MyD-88, crucial in IBD development [504]