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Long term exposed cells at intermediate concentrations were harvested for measurements of mitochondrial function, mtDNA gene expression or mtDNA methylation, specifically at 3.5% (cultured for 4 weeks), 5% (10 weeks), 6% (12 weeks), and 10% (25 weeks)

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Vaughan Rees Director of the Center for Global Tobacco Control , Lecturer on Social and Behavioral Sciences Scientists and advocates working in tobacco control have been concerned about the influence of menthol cigarettes for decades
From differential DNA methylation in COPD to mitochondria: regulation of AHRR expression affects airway epithelial response to cigarette smoke

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