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Description
A comprehensive literature search was conducted across the PubMed, Embase, and Google Scholar databases for peer-reviewed articles published from inception through June 15, 2026, focusing on the landmark SURPASS, SURMOUNT, and SUMMIT trial programs, relevant cardiorenal post hoc analyses, emerging body recomposition trials, and real-world cohort-switching protocols
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5 Targeted Probiotics, including spore-based strains that survive stomach acid to support microbiome health

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GLP-1 medications such as semaglutide typically begin affecting appetite within days, though meaningful weight loss usually emerges after 4 to 8 weeks of consistent treatment at therapeutic doses
