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If patients receive GLP1 medications outside their primary health system (for example, from telehealth) or change providers during the treatment, the EHR data collected in our study may not capture the full course of treatment, and this may explain our observation of generally shorter treatment durations, and hence less weight loss, recorded in EHRs

Mechanistically, the majority of senolytics induce senolysis by targeting and inhibiting of senescence cell antiapoptotic pathways (SCAPs), among which are ephrin-B 1/3 (EFNB1/3), p53, the heat shock protein 90 (HSP90), and anti-apoptotic members of B-cell lymphoma-2 (BCL-2) family proteins, such as BCL-extra large (BCL-xL) and BCL-w

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