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GLP-1 agonists give an average reduction of HbA1c of 11 mmol/mol in comparison with placebo (11) and SGLT2 inhibitors give an average HbA1c reduction of 7-9 mmol/mol (12)

And weve been in leadership committees across the entire spectrum of multidistrict litigation

This evolution prompts a critical question for trial design: Is placebo still the most informative comparator in obesity trials

Despite their efficacy in managing obesity and metabolic disorders, GLP-1 and GIP receptor agonists can cause side effects, which are a common reason for therapy discontinuation

Most people feel substantial effects