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Neurology 81(13):11591165 Rosser DA et al (2003) How sensitive to clinical change are ETDRS logMAR visual acuity measurements

Surprisingly, our results show that administration of Sema reduces glycolysis levels and promotes pyruvate into the TCA cycle, thereby increasing ATP production (Fig

While the evidence is thin, one study in the paper above did show nearly half of patients on methadone experienced excessive sweating

More serious risks include pancreatitis, gallbladder disease, acute kidney injury from dehydration, and hypoglycemia (when used with insulin or sulfonylureas)
Fralick M, Kim SC, Schneeweiss S, Everett BM, Glynn RJ, Patorno E
