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Significance statement ![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

A stratified next-generation trial could test whether semaglutide works in the right patients even at the same 14 mg dose that failed in an unselected population

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Semaglutide was effective in lowering the concentration of low density lipoprotein (0.16 mmol/L (0.30 to 0.02)) and total cholesterol (0.48 mmol/L (0.84 to 0.11))