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11 While varenicline has demonstrated efficacy for smoking cessation, there are concerns about cardiovascular side effects and its use is recommended only in patients with stable cardiovascular disease by the ACC's ECDP on Tobacco Cessation

In Proceedings of the 2005 ACM symposium on Applied computing 141145

The only notable difference was that the cigar was wrapped in tobacco leaf rather than a white paper but on opening they found there was also a paper tube within the leaf wrap to hold the tobacco

doi: 10.1007/s00213-005-2225-3

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