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doi: 10.1097/RTI.0b013e318231535b

Despite the fact that BSO does not affect overall cellular PDI levels, we found that cells with selective PDI knockdown clearly manifest a markedly-reduced sensitivity to BSO-induced ferroptosis

5) NPT MD (T = 310 K, t = 24 ps, p = 1 bar) with Berendsen thermo- and barostat ( T = 0.1 ps, p = 2.0 ps, separate coupling for solute and solvent) and no restraints

(Antioxidant System) - : GSH (first-line antioxidant) Reactive Oxygen Species (ROS) Lipid Peroxides () - : GSH (Vitamin E) Lipid Peroxyl Radicals (LOO- ) Vitamin E (oxidized)+GSHVitamin E (reduced)+GSSG 2

Meanwhile, the median number of gH2AX foci per cell rose significantly in the control group [56]

In TME, tumor cells compete with various immune cells for the utilization of Gln