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We were able to show that the circulating form of DPP4 (sDPP4), which lacks the cytoplasmic domain and the transmembrane region, is cleaved off the membrane of human adipocytes and smooth muscle cells in a process called shedding by the involvement of matrix metalloproteases (MMPs) (3)

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10 Key Facts About GLP-1 and Its Impact on Health (2026) A comprehensive clinical guide explaining 10 key facts about GLP-1 receptors, gastric emptying, blood-brain barrier passage, muscle preservation, and cardioprotection

Marre M, Shaw J, Brandle M, et al

Our study aims to investigate the impact of GLP-1RA initiation on risks of AF/Aflutter and stroke in patients with T2D treated with levothyroxine, compared to sodium-glucose cotransporter 2 (SGLT2) inhibitors
