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Microglia-derived HIV Nef+ exosome impairment of the blood-brain barrier is treatable by nanomedicine-based delivery of Nef peptides

Many peptide- and protein-based drugs are pH-sensitive and prone to hydrolysis, deamidation, or oxidation outside their optimal pH range, which can compromise therapeutic efficacy (Illum, 2003

doi: 10.1016/j.bbrc.2019.10.006 131 HansonLRRoeytenbergAMartinezPMCoppesVGSweetDCRaoRJet al

tuberculosis in the presence of exogenous B12 resulted in selection of mutations in the MetE riboswitch (Warner et al., 2007), but there is no evidence of equivalent SNPs in clinical isolates with MetH a deletions or mutations (Figure 5)

Lack of effect of recombinant human growth hormone on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men

the active compounds can be prepared with carriers that will protect the compound against rapid release, such as a controlled release Biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters, and polylactic acid
