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The gross-to-net bubble keeps inflating: Rebates cut list prices roughly in half Patients cover ~22% of net costs Insurers capture ~90% of rebate value Despite higher list prices, the actual net cost per GLP-1 prescription has stayed flat

Interestingly, about half of users stop taking these medications within a year, a dropout rate similar to lifestyle programs

Even the most affordable semaglutide providers charge significantly more than resM

Another challenge is that extreme diets are difficult to sustain

Pleased This is only my first month using Semaglutide so my hunger is no entirely low but I can tell its slightly better

Since it is often suggested that the cocaine-induced hyperactivity might be a correlate of dopamine release in the NAc, the lack of an effect of EX4 on cocaine hyperactivity might indicate that the reduction in reward value of cocaine occurs via a mechanism outside of or downstream of the dopamine release