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The ultimate success of oral peptides or recombinant protein drugs requires a large number of clinical studies and verification by real-world patients after launch

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20 , 21 As such, bariatric surgery is typically reserved for individuals with severe obesity (body mass index [BMI] 40 kg/m 2 or BMI 35 kg/m 2 with obesity-related comorbidities) who have not achieved sufficient weight loss with other interventions
