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While analyses restricted to participants with established cardiovascular disease yielded MACE results that were directionally consistent with the overall analysis, conclusions are limited because subgroup estimates were based on trial-level reporting rather than individual participant data, and included studies continued to differ in patient characteristics, definitions of established cardiovascular disease, background therapies, and trial era
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Why Tirzepatide Is Not Recommended During Pregnancy Tirzepatide has not been formally studied in pregnant women, which means its effects on fetal development, placental function, and pregnancy outcomes are not well documented in clinical trials
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