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However, older adults may need slower titration

The reason for the observed BP reduction with SGLT-2 inhibitors involves several pathways including a modest diuretic effect (54), weight reduction and potentially some sodium depletion (55)

7 BernardG.ShevellM.I (2008)
humidity, 50 10%) under a 12 h12 h lightdark cycle (light, 01:00 to 13:00) with ad libitum access to chow diet (Brogaarden, Altromin, 1324) and tap water

PLoS ONE 12 , e0172921 (2017)
