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However, the angiogenesis induced by hypoxia in tumors is typically aberrant and disorganized, resulting in leaky, tortuous, and poorly functional blood vessels (152)

S., Arnold, S

And once we understood the mechanism, we could target it directly

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[DOI] [PubMed] [Google Scholar] 48.Scenario: management of anaemia - vitamin B 12 and folate deficiency

The liberated p53 then transcription-independently activates the pro-apoptotic protein BAX, thereby triggering the execution phase of apoptosis