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However, the opening of putative NSC conductance only explains the acute effects of Ex-4c in a minor population of arcuate POMC neurons, while the closure of K ATP channels largely accounts for the activation of arcuate POMC neurons by Ex-4c (Fig

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An increasing concentration of unlabeled GLP-2(133) or teduglutide (ranging from 0.1 nM to 1 M) followed by a fixed concentration of [ 125 I]GLP-2(133, M10Y) (1015 pM) was added to the cells and incubated for 4 h at 4 C