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The daily dosages were divided into two or three doses, except for one patient who took the whole daily dose of 100 mg in the evening

While research continues to uncover more specific pathways, the general understanding is that cellular damage accumulates over time, leading to malignant transformation

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Further, smoking, which is known to increase the levels of receptors for nicotine in the brain, had this effect in both groups, although it was blunted in schizophrenia

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