will compound pharmacies stop making semaglutide versions of GLP-1 drugs for weight loss halted by FDA Compounded Semaglutide & Tirzepatide 2025:

Meanwhile, the oral Wegovy offers comparable efficacy with 16.6% body weight loss, offering an appealing alternative for those who prefer medication without injections

But its not a simple problem of low GLP-1 = bad

[DOI] [PubMed] [Google Scholar] 16.Risk of gastrointestinal adverse events associated with glucagon-like peptide-1 receptor agonists for weight loss

For me, its been less about weight loss and more about metabolic health + muscle retention

This weight regain is not due to medication "dependence" in the traditional sense, but rather reflects the underlying biology of obesity as a chronic condition

GLP-1RAs aid in weight loss by regulating the gut-brain axis and interacting with leptin, while weight loss can alleviate the harmful effects of obesity on the body, particularly in knee OA, by reducing joint loading and inflammation