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UK tobacco harm reduction advocate Clive Bates previously opined: The only mystery is why the skies over Tokyo are not dark with chartered planes bringing officials from WHO, FDA, Truth Initiative, the Campaign for Tobacco-Free Kids, the European Commission and others on an emergency mission to learn about this most extraordinary shift

These covariates include (1) the e-cigarette product (e.g., type of device, nicotine content and delivery, flavorings or other contents of the e-liquid), (2) pattern of current use (e.g., frequency of use, duration of use), and (3) user characteristics (particularly interest in quitting and prior history of e-cigarette use, but also demographics and smoking history) (Malas et al., 2016)

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Association of cardiovascular disease risk factors with exclusive smokeless tobacco use among us males: cross-sectional analysis of NHANES data 20032018

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