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Since dermal periostin in PN shows no significant correlation with other pruritogenic mediators in the dermis (including IL-31, IL-31R, and OSMR), it might be an independent contributor to pruritus in PN (64)

The skin of the individual is damaged by the sun

Authors noted that the approval of DMTs may affect recruitment if patients choose approved over experimental therapies

If people are raving about your glowy skin or energy, thats a good sign

In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different

Vitamin B12, especially when injected, has been linked to better language, cognition, and attention